No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma
نویسندگان
چکیده
منابع مشابه
Type 5 phosphodiesterase inhibition: the focus shifts to the heart.
Of the molecules that transmit an extracellular message to alter cardiomyocyte physiology, the cyclic nucleotides are among the better understood as regulators of cell function. The relatively recent identification of nitric oxide (NO) as a stimulus of cGMP production by soluble guanyl cyclase,1 as well as of the natriuretic peptides as a stimulating membrane-bound guanylate cyclase,2 has led t...
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There are no published controlled clinical trials of regular phosphodiesterase type 5 inhibitor therapy as a long-term treatment of hypertension. In a randomized, double-blind, 2-way crossover study, 25 otherwise untreated hypertensive subjects were administered 50 mg of sildenafil or matched placebo 3 times daily for 16 days, and the effects on ambulatory blood pressure (BP), clinic BP, arteri...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Relation of phosphodiesterase type 5 inhibitors and malignant melanoma: a meta-analysis and systematic review
Data on the association between using PDE5 inhibitors and malignant melanoma are conflicting. To estimate the relation of using PDE5 inhibitors with risk of malignant melanoma, Medline (Ovid) and Embase (Ovid) databases were searched up to February 2017, and a random effects model was used to calculate the summary risk estimates. Five observational studies were included. Five studies reports en...
متن کاملPhosphodiesterase 5 Inhibition to Treat Essential Hypertension
Treatment of hypertension is a challenging task in cardiovascular medicine. The obviously simple concept that blood pressure (BP) must be “normalized” faces the intrinsic difficulty to decrease BP values, because the effectiveness of available drug classes in terms of BP reduction is in many cases not adequate to reach the therapeutic targets.1 One possible means of overcoming this limitation i...
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ژورنال
عنوان ژورنال: The World Journal of Men's Health
سال: 2019
ISSN: 2287-4208,2287-4690
DOI: 10.5534/wjmh.180050